Tracking Resistance to Artemisinin Collaboration (TRAC)
TRAC is investigating the scope and spread of parasite resistance to artemisinin-based therapies at sites across Asia and Africa. The first TRAC study has been completed. This multi-centre, open-label randomised trial studied the clearance rates of peripheral blood P. falciparum parasitaemias in patients with acute uncomplicated falciparum malaria treated with two different doses of artesunate. Findings were used to validate the recently discovered kelch13 marker of artemisinin resistance. Working with MalariaGEN, TRAC samples have been sequenced and analysed for features of population genetics and signatures of selection, and contributed to the genetic basis of a genome-wide associations study for genetic markers of artemisinin resistance. Where samples were found to contain P. vivax data, for example due to mixed infection, this data was contributed to the P. vivax Genome Variation project.
Summary
- 1,173 Samples
- 15 Locations
- 64 Publications
Samples/Year
QC Pass
Samples that passed Whole-Genome Sequencing Quality Control (QC)
Resistance
Predicted resistance status for main antimalarial drug treatments from molecular markers
Locations
Attapeu
Summary
Samples/Year
QC Pass
Samples that passed Whole-Genome Sequencing Quality Control (QC)
Resistance
Predicted resistance status for main antimalarial drug treatments from molecular markers
Bago
Summary
Samples/Year
QC Pass
Samples that passed Whole-Genome Sequencing Quality Control (QC)
Resistance
Predicted resistance status for main antimalarial drug treatments from molecular markers
Binh Phuoc
Summary
Samples/Year
QC Pass
Samples that passed Whole-Genome Sequencing Quality Control (QC)
Resistance
Predicted resistance status for main antimalarial drug treatments from molecular markers
Chittagong
Summary
Samples/Year
QC Pass
Samples that passed Whole-Genome Sequencing Quality Control (QC)
Resistance
Predicted resistance status for main antimalarial drug treatments from molecular markers
Kachin
Summary
Samples/Year
QC Pass
Samples that passed Whole-Genome Sequencing Quality Control (QC)
Resistance
Predicted resistance status for main antimalarial drug treatments from molecular markers
Kinshasa
Summary
Samples/Year
QC Pass
Samples that passed Whole-Genome Sequencing Quality Control (QC)
Resistance
Predicted resistance status for main antimalarial drug treatments from molecular markers
Kwara
Samples/Year
QC Pass
Samples that passed Whole-Genome Sequencing Quality Control (QC)
Resistance
Predicted resistance status for main antimalarial drug treatments from molecular markers
Mandalay
Summary
Samples/Year
QC Pass
Samples that passed Whole-Genome Sequencing Quality Control (QC)
Resistance
Predicted resistance status for main antimalarial drug treatments from molecular markers
Pailin
Summary
Samples/Year
QC Pass
Samples that passed Whole-Genome Sequencing Quality Control (QC)
Resistance
Predicted resistance status for main antimalarial drug treatments from molecular markers
Preah Vihear
Summary
Samples/Year
QC Pass
Samples that passed Whole-Genome Sequencing Quality Control (QC)
Resistance
Predicted resistance status for main antimalarial drug treatments from molecular markers
Pursat
Summary
Samples/Year
QC Pass
Samples that passed Whole-Genome Sequencing Quality Control (QC)
Resistance
Predicted resistance status for main antimalarial drug treatments from molecular markers
Ranong
Summary
Samples/Year
QC Pass
Samples that passed Whole-Genome Sequencing Quality Control (QC)
Resistance
Predicted resistance status for main antimalarial drug treatments from molecular markers
Ratanakiri
Summary
Samples/Year
QC Pass
Samples that passed Whole-Genome Sequencing Quality Control (QC)
Resistance
Predicted resistance status for main antimalarial drug treatments from molecular markers
Sisakhet
Summary
Samples/Year
QC Pass
Samples that passed Whole-Genome Sequencing Quality Control (QC)
Resistance
Predicted resistance status for main antimalarial drug treatments from molecular markers
Tak
Summary
Samples/Year
QC Pass
Samples that passed Whole-Genome Sequencing Quality Control (QC)
Resistance
Predicted resistance status for main antimalarial drug treatments from molecular markers