Genotyping P. falciparum and P. vivax in Madagascar

The island of Madagascar is geographically situated in the south western region of the Indian Ocean and amongst malaria-endemic countries, its situation is unique: historically, human migration has occurred from both Africa and Asia; Duffy negative people can be susceptible to P. vivax; there is an absence of pfcrt mutant P. falciparum despite the official use of chloroquine to treat malaria for six decades (1945 - 2005). This study is mainly investigating Plasmodium samples collected directly from patients with uncomplicated malaria, as well as tracking malaria parasites and genetic markers of drug resistance in these parasites. This long-term study is contributing to the Plasmodium Diversity Network Africa (PDNA), an African-led network investigating the genetic diversity and drug resistance of Plasmodium across Africa.

Summary

Samples/Year

QC Pass

Samples that passed Whole-Genome Sequencing Quality Control (QC)

Resistance

Predicted resistance status for main antimalarial drug treatments from molecular markers

Locations

Fianarantsoa

Samples/Year

QC Pass

Samples that passed Whole-Genome Sequencing Quality Control (QC)

Resistance

Predicted resistance status for main antimalarial drug treatments from molecular markers

Mahajanga

Samples/Year

QC Pass

Samples that passed Whole-Genome Sequencing Quality Control (QC)

Resistance

Predicted resistance status for main antimalarial drug treatments from molecular markers