Investigating artemisinin resistance emergence on Thai-Burmese border

P. falciparum resistance to artemisinin derivatives emerged on the Thai Myanmar border between 2000 and 2010. The Shoklo Malaria Research Unit (SMRU) has collected phenotypic data on more than 3,000 patients with uncomplicated hyperparasitaemia and stored packed red blood cells for over 600 at the time of admission. This constitutes a unique collection of samples available for genomic analysis to determine changes in the parasite population structures and to identify potential molecular markers associated with resistance to artesunate.

Summary

Samples/Year

QC Pass

Samples that passed Whole-Genome Sequencing Quality Control (QC)

Resistance

Predicted resistance status for main antimalarial drug treatments from molecular markers

Locations

Tak

Samples/Year

QC Pass

Samples that passed Whole-Genome Sequencing Quality Control (QC)

Resistance

Predicted resistance status for main antimalarial drug treatments from molecular markers