Documentation

This is a preview of the MalariaGEN Pf8 data release which contains genome variation data on 33,000 samples of Plasmodium falciparum from around the world. This data exploration tool describes the partner studies that have contributed samples and data to Pf8, and provides summary information about genetic markers of drug resistance in these samples.

For the estimation of drug resistance, we focus on the following molecular markers for each drug described:

Artemisinin: Pf3D7_1343700; PfKelch13 – WHO classified resistance mutation within codons 349 - 726

Chloroquine: PF3D7_0709000; PfCRT – Codon 76

Mefloquine: PF3D7_0523000; PfMDR1 – whole gene amplification status

Piperaquine: Pf3D7_1408000 & Pf3D7_1408100; Pfplasmepsin2 & 3 – gene amplification status of both genes

Pyrimethamine: PF3D7_0417200; PfDHFR – Codon 108

Sulfadoxine: PF3D7_0810800; PfDHPS – Codon 437

To find out more about previous MalariaGEN P. falciparum data resources, follow this link to the Pf7 data release and the accompanying publication in Wellcome Open Research.